BIOGRAPHY
Wan Gi Byun was born in 1993 in Daegu, Korea. He received his B.S. degree in Department of Chemistry at Seoul National University, Korea in 2015. He has joined our group in spring, 2015. In 2022, he received his Ph.D. degree in Chemistry under the supervision of Prof. Seung Bum Park in Seoul National University. He is now a post-doctoral researcher in Department of Chemistry, Seoul National University.
RESEARCH
He is interested in function of biomacromolecules and drug discovery.
PUBLICATION LISTS
(10) Son, H.†; Kim, D.†; Kim, S.; Byun, W. G.; Park, S. B. Unveiling the Structure-Fluorogenic Property Relationship of Seoul-Fluor-Derived Bioorthogonal Tetrazine Probes. Angew. Chem. Int. Ed. 2024, e202421982.
(9) Lee, M.†; Byun, W. G.†; Son, S.; Park, S. B. Development of a Molecular Glue-based Lin28 Degrader to Regulate Cellular Proliferation and Stemness. Chem. Commun. 2024, 60, 12525–12528. (†equal contribution, selected as Outside Front Cover article)
(8) Byun, W. G.; Lee, M.; Ko, M.; Lee, J. H.; Yi, S.; Lee. J.; Kim, S.; Park, S. B. Broad-Spectrum Antiviral Agents against SARS-CoV-2 Variants Inhibit the Conserved Viral Protein Nsp1–RNA Interaction. Angew. Chem. Int. Ed. 2024, e202405472.
(7) Jang, H.-J.; Yoon, Y. J.; Choi, J.; Lee, Y.-J.; Lee, S.; Cho, W.; Byun, W. G.; Park, S. B.; Han, D. C.; Kwon, B.-M. S-Benproperine, an Active Stereoisomer of Benproperine, Suppresses Cancer Migration and Tumor Metastasis by Targeting ARPC2. Pharmaceuticals 2022, 15, 1462.
(6) Byun W. G.†; Lim, D.†; Park, S. B. Small-Molecule Modulators of Protein–RNA Interactions. Curr. Opin. Chem. Biol. 2022, Accepted. (†equal contribution)
(5) Byun, W. G.; Lee, J.; Kim, S.; Park, S. B. Harnessing Stress Granule Formation by Small Molecules to Inhibit the Cellular Replication of SARS-CoV-2. Chem. Commun. 2021, 57, 12476–12479.
(4) Byun W. G.†; Lim, D.†; Park, S. B. Discovery of Small-Molecule Modulators of Protein–RNA Interactions by Fluorescence Intensity-Based Binding Assay. ChemBioChem 2020, 21, 818–824. (†equal contribution, selected as Front Cover article)
(3) Kim, H.; Jo, A.; Choi, S.-S.; Nam, H.; Byun, W. G.; Bae, H.; Choi, J. H.; Park, S. B. Rational Design and Synthesis of Reversible Covalent PPARγ Antagonistic Ligands Inhibiting Ser273 Phosphorylation. Asian. J. Org. Chem. 2019, 8, 1698–1706.
(2) Lim, D.†; Byun, W. G.†; Park, S. B. Restoring Let-7 microRNA Biogenesis Using a Small-Molecule Inhibitor of the Protein–RNA Interaction. ACS Med. Chem. Lett. 2018, 9, 1181–1185. (†equal contribution)
(1) Lim, D.; Byun, W. G.; Koo, J. Y.; Park, H.; Park, S. B. Discovery of a Small-Molecule Inhibitor of Protein–MicroRNA Interaction Using Binding Assay with a Site-Specifically Labeled Lin28. J. Am. Chem. Soc. 2016, 138, 13630–13638.
HONORS AND AWARDS
(3) Best Poster Presentation Award, 14th AFMC International Medicinal Chemistry Symposium (AIMECS 2023), Asian Federation for Medicinal Chemistry. 06/2023
(2) The Best Ph.D. Dissertation Award, College of Natural Sciences, Seoul National University. 02/2022
(1) The Presidential Science Scholarship, Korea Student Aid Foundation (KOSAF). 03/2011 – 02/2015